Cyclic pyridyl-n-(1,3,4)-thiadiazol-2-yl-benzene...

C - Chemistry – Metallurgy – 07 – D

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C07D 417/12 (2006.01) A61K 31/4439 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2710441

The invention relates to cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARgamma agonist activity. What is described are compounds of the Formula (I), in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

L'invention porte sur des N-[1,3,4]-thiadiazol-2-yl-benzènesulfonamides cycliques et sur leurs sels physiologiquement acceptables et dérivés physiologiquement fonctionnels montrant une activité agoniste de PPARdelta ou PPARdelta et PPARgamma. On décrit des composés représentés par la Formule (I), dans laquelle les radicaux sont tels que définis, et leurs sels physiologiquement acceptables et des procédés permettant de les préparer. Les composés sont appropriés pour le traitement et/ou la prévention de troubles du métabolisme des acides gras et de troubles de l'utilisation du glucose ainsi que de troubles dans lesquels la résistance à l'insuline est mise en jeu et de la démyélinisation et d'autres troubles neurodégénératifs du système nerveux central et périphérique.

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