Modified release formulations and methods of treating...

A - Human Necessities – 61 – K

Patent

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A61K 9/20 (2006.01)

Patent

CA 2643295

Methods and formulations for treating inflammatory bowel disease are disclosed. The methods and formulations include, but are not limited to, methods and formulations for delivering effective concentrations of 4-aminosalicylic acid and/or 5-aminosalicylic acid, and pharmaceutically acceptable salts and pro-drugs thereof, to affected areas of the intestine, i.e., distal gut. The methods and formulations comprise modified-release elements, providing for drug delivery to the affected or desired area. Diseases and conditions treatable with the present invention include Crohn's disease and ulcerative colitis.

L'invention concerne des méthodes et des formulations servant à traiter une maladie intestinale inflammatoire. Les méthodes et les formulations comprennent, entre autres, des méthodes et des formulations permettant d'administrer au niveau de régions affectées de l'intestin, à savoir, l'intestin distal, des concentrations efficaces d'acide 4-aminosalicylique et/ou d'acide 5-aminosalicylique, ainsi que des sels acceptables pharmaceutiquement et des promédicaments associés. Les méthodes et les formulations comprennent des éléments à libération modifiée, ce qui permet d'administrer des médicaments au niveau de la région affectée ou désirée. Des maladies et des troubles pouvant être traités par les méthodes et les formulations de cette invention englobent la maladie de Crohn et la colite ulcéreuse.

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