A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2631181
The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of an Sp35 antagonist. Additional methods include methods for inhibiting the binding of the Sp35 polypeptide with the ErbB2 polypeptide and a method for increasing ErbB2 phosphorylation by contacting oligodendrocytes with an effective amount of a composition comprising an Sp35 antagonist of the invention. Further embodiments of the invention include methods of inhibiting the binding of the Sp35 polypeptide with the ErbB2, increasing ErbB2 phosphorylation and promoting oligodendrocyte differentiation comprising contacting oligodendrocyte or oligodendrcoyte progenitor cells with an ErbB2 binding agent.
L'invention porte sur des méthodes de traitement de maladies, troubles, et lésions liés à la démyélination et à la dysmyélination, dont la sclérose en plaques, par administration d'un antagoniste du Sp35. D'autres méthodes consistent: à inhiber la fixation du polypeptide Sp35 sur le polypeptide ErbB2; à accroître la phosphorylation de l'ErbB2 en mettant en contact des oligodendrocytes avec une quantité efficace d'une composition comprenant un antagoniste du Sp35 de l'invention; à inhiber la fixation du polypeptide Sp35 sur l'ErbB2; à accroître la phosphorylation de l'ErbB2; et à promouvoir la différenciation des oligodendrocytes en mettant en contact des cellules progénitrices d'oligodendrocyte avec un agent de fixation à l'ErbB2.
Mccoy John
Mi Sha
Pepinsky R. Blake
Biogen Idec Ma Inc.
Gowling Lafleur Henderson Llp
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