Antitumor antisense sequences directed against r1 and r2...

Details Antitumor antisense sequences directed against r1 and r2... Antitumor antisense sequences directed against r1 and r2...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 9/02 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2262776

Compounds and methods for modulating cell proliferation, preferably inhibiting the proliferation of tumor cells are described. Compounds that may be used to modulate cell proliferation include inhibitors of ribonucleotide reductase expression, that is, inhibitors of transcription or translation of the gene encoding ribonucleotide reductase. Antisense oligonucleotides complementary to regions of ribonucleotide reductase gene are particularly useful inhibitors.

On décrit des composés et procédés de modulation de la multiplication cellulaire, de préférence, d'inhibition de la multiplication de cellules tumorales. Les composés que l'on peut utiliser pour moduler cette multiplication cellulaire comprennent des inhibiteurs de l'expression de la ribonucléotide réductase, c'est-à-dire des inhibiteurs de la transcription ou translation du gène codant la ribonucléotide réductase. Des oligonucléotides antisens complémentaires de régions du gène de ribonucléotide réductase constituent notamment des inhibiteurs utiles.

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