Compositions and methods for modulating .beta.-amyloid

Details Compositions and methods for modulating .beta.-amyloid Compositions and methods for modulating .beta.-amyloid

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12N 9/02 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2126451

2126451 9313114 PCTABS00024 Compositions and methods are provided for the modulation of expression of the gene encoding .beta.-amyloid in both the normal and mutant forms. Oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from the .beta.-amyloid precursor (.beta.APP) gene encoding .beta.-amyloid, having nucleotide units sufficient in identity and number to effect such specific hybridization. Oligonucleotides specifically hybridizable with a translation initiation site or with the codon-717 mutation of .beta.APP are provided. Such oligonucleotides can be used for diagnostics as well as for research purposes. Methods are also disclosed for modulating .beta.-amyloid expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of the mutant .beta.APP gene. Methods for diagnosis, detection and treatment of conditions arising from the mutation of the .beta.APP gene are also disclosed.

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