A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7088 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2538729
The present invention provides compositions and methods for treating prostate cancer. The composition comprises a morpholino antisense compound having uncharged phosphorus-containing backbone linkages and a base sequence that is complementary to a target region containing at least 12 contiguous bases in a preprocessed or processed human androgen receptor transcript. The method is designed for treating prostate cancer in a subject having a hormone-refractory (androgen-independent) prostate cancer.
La présente invention concerne des compositions et des méthodes de traitement du cancer de la prostate, la composition renferme un composé antisens morphilono ayant des liaisons d'un squelette non chargé contenant du phosphore et une séquence de base complémentaire à la région cible contenant au moins 12 bases contiguës se trouvant dans un produit de la transcription d'un récepteur d'androgènes humain prétraité ou traité. La méthode permet de traiter le cancer de la prostate chez un patient souffrant d'un cancer de la prostate réfractaire aux hormones (androgéno-indépendant).
Devi Gayathri R.
Iversen Patrick L.
Avi Biopharma Inc.
Gowling Lafleur Henderson Llp
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