Means and method for hormonal contraception and/or the...

A - Human Necessities – 61 – K

Patent

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A61K 31/57 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2179422

Means for hormonal contraception and/or acne treatment, having two hormone constituents packaged spatially separately in a packaging unit and intended for temporally sequential administration, each of said hormone constituents being composed of a plurality of daily hormone units accommodated spatially separately and individually removable in the packaging unit, whereby a first of said hormone constituents essentially exclusively contains an estrogen preparation effecting a disturbance of the follicle stimulation as active hormonal ingredient, by contrast whereto the second hormone constituent contains an estrogen preparation and a gestagen preparation in a dosing at least adequate for ovulation inhibition in combination, and the total number of daily hormone units is equal to the total number of days of the desired cycle, said first hormone constituent comprises 5-14 and said second hormone constituent comprises 23-14 daily units, and the plurality of daily units of said first hormone constituent is lower than the plurality of daily units of said second hormone constituent, characterized by such an arrangement of the daily units in the packaging unit that the daily units of the second hormone constituent are characterized as those to be taken first and the daily units of the first hormone constituent are characterized as those to be taken following thereupon, whereby the daily units of the second hormone constituent do not contain the combination of a biogenous estrogen and a synthetic estrogen.

Agents pour la contraception hormonale et/ou pour le traitement de l'acné, comprenant deux composants hormonaux préparés à part et séparés l'un de l'autre dans une unité d'emballage, destinés à être administrés séquentiellement, constitués chacun par une pluralité de doses quotidiennes hormonales disposées dans l'unité d'emballage, séparément les unes des autres et prélevables individuellement. Un premier desdits composants hormonaux renferme sensiblement exclusivement, comme substance active, une préparation oestrogène provoquant un empêchement de la maturation folliculaire, le deuxième des composants hormonaux renfermant, par contre, en combinaison, une préparation oestrogène et une préparation progestative en au moins une dose suffisante pour la mise au repos de l'ovaire, le nombre total de doses quotidiennes hormonales étant égal au nombre total de jours du cycle souhaité, c'est-à-dire 5 à 14 doses quotidiennes du premier composant hormonal comprenant 23 à 14 doses quotidiennes du deuxième, le nombre de doses quotidiennes du premier composant hormonal étant plus faible que le nombre de doses quotidiennes du deuxième composant hormonal. Lesdits agents se caractérisent en ce que la disposition des doses quotidiennes dans l'unité d'emballage est telle que les doses quotidiennes du deuxième composant hormonal sont propres à être absorbées en premier, les doses quotidiennes du deuxième composant hormonal ne renfermant pas d'oestrogène biogénique combiné à un oestrogène synthétique.

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