A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01) A61B 5/055 (2006.01)
Patent
CA 2540131
The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is a gadolinium. Another aspect of the invention relates to a compound comprising three biotin moieties and a pharmaceutical agent covalently bound to a heterocyclic core. In certain embodiments, the pharmaceutical agent is an antibiotic, antiviral, or radionuclide. Another aspect of the present invention relates to a method of treating disease involving administering the compounds of the invention to a mammal. Another aspect of the present invention relates to a method of acquiring a magnetic resonance image using the compounds of the invention.
L'invention concerne en règle générale des composés à base de biotine utiles comme agents d'imagerie et agents d'administration de médicaments. Selon un autre aspect, les composés subissent une chélation avec un atome de métal. En mode de réalisation préféré, le métal est gadolinium. Selon un autre aspect, l'invention concerne un composé qui renferme trois fractions de biotine et un agent pharmaceutique à liaison covalente avec un noyau hétérocyclique. Selon certaines variantes, l'agent pharmaceutique est antibiotique, agent antiviral ou radionuclide. Selon un autre aspect, l'invention concerne un procédé de traitement de maladie consistant à administrer les composés à un mammifère. Selon un autre aspect, on décrit un procédé d'acquisition d'IRM par le biais des composés décrits.
Elmaleh David R.
Fischman Alan J.
Shoup Timothy M.
Riches Mckenzie & Herbert Llp
The General Hospital Corporation
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