Isoquinolines as urokinase inhibitors

Details Isoquinolines as urokinase inhibitors Isoquinolines as urokinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 217/22 (2006.01) A61K 31/47 (2006.01) C07D 221/00 (2006.01) C07D 317/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 491/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2306782

Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is H and the other is N-C(NH2)2 or NHC(-NH)NH2, and the other substituents are as defined herein, are urokinase (uPA) inhibitors.

L'invention concerne des composés de formule (I) et leurs sels pharmaceutiquement acceptables, dans laquelle l'un des R<1> et R<2> représente H et l'autre représente N=C(NH2)2 ou NHC(=NH)NH2 et les autres substituants sont tels que définis. Les composés sont des inhibiteurs d'urokinase (uPA).

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