C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 477/20 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2241092
A 1-methylcarbapenem compound represented by the following formula (I): Image wherein R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or an ester residue; and A represents a substituted aminoalkanoylaminopyrrlidin- 1-ylcarbonyl group, or the like, or a pharmacologically- acceptable salt thereof. 1-Methylcarbapenem compounds of the present invention have excellent antibacterial activity and they are useful agents for the prevention or treatment of infectious diseases.
On décrit des composés à base de 1-méthylcarbapenem, ou leurs sels pharmacologiquement acceptables, correspondant à la formule générale (1) dans laquelle R<1> représente hydrogène ou alkyle inférieur; R<2> représente hydrogène ou un résidu d'ester; et A représente propylaminopyrrolidin-1-ylcarbonyle substitué, aminoalcanoylaminopyrrolidin-1-ylcarbonyle substitué, 1-hydroxy-2-(aminoalkylpyrrolidine substituée-1-ylcarbonyl)éthyle, 1-hydroxy-2-(pipérazine substituée-1-ylcarbonyl)éthyle, 1-hydroxy-2-(pyrrolidinylaminocarbonyl substitué)éthyle, etc. Grâce à leur excellente activité antibactérienne, ces composés à base de 1-méthylcarbapenem se révèlent efficaces pour prévenir ou soigner des maladies infectieuses.
Ishikawa Katsuya
Kawamoto Isao
Kojima Katsuhiko
Ohya Satoshi
Shimoji Yasuo
Marks & Clerk
Sankyo Company Limited
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