C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) C07K 14/47 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2497222
The present invention provides a method of increasing heterologous protein expression/production in a cell by controlling proteolysis in the post ER compartment of the cell. Proteolysis can be controlled by limiting/preventing export of proteins from the ER to the post ER compartment of the cell and/or by re-directing proteins from the vacuolar sorting route back to the ER or on towards the cell surface.
La présente invention concerne une méthode visant à augmenter l'expression/production de protéines hétérologues dans une cellule par régulation de la protéolyse dans le compartiment post réticulum endoplasmique de la cellule. La protéolyse peut être régulée par limitation/prévention de l'exportation de protéines du réticulum endoplasmique au compartiment post réticulum endoplasmique de la cellule et/ou par réorientation des protéines de la voie de triage vacuolaire vers le réticulum endoplasmique ou vers la surface cellulaire.
Ridout & Maybee Llp
University Of Leeds
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