Methods for treating respiratory disorders

Details Methods for treating respiratory disorders Methods for treating respiratory disorders

A - Human Necessities

61

K

A61K 31/502 (2006.01) A61K 31/34 (2006.01)

Patent

CA 2624933

The invention provides methods for treating respiratory disorders in a patient in need thereof comprising administering an effective amount of (i) at least one hydralazine compound or a pharmaceutically acceptable salt thereof, (ii) isosorbide dinitrate and/or isosorbide mononitrate, and (iii) optionally at least one therapeutic agent. The hydralazine compound may be hydralazine hydrochloride. The respiratory disorders may be chronic obstructive pulmonary disease, pulmonary hypertension, emphysema, asthma, cystic fibrosis and bronchitis.

La présente invention concerne des méthodes de traitement de troubles respiratoires chez un patient souffrant d'une telle affection, lesdites méthodes comprenant l'administration d'une quantité efficace de (i) au moins un dérivé d'hydralazine ou d'un sel de qualité pharmaceutique dudit composé, (ii) dinitrate d'isosorbide et/ou mononitrate d'isosorbide, et (iii) éventuellement au moins un agent thérapeutique. Le dérivé d'hydralazine peut être le chlorhydrate d'hydralazine. Les troubles respiratoires peuvent être la bronchopneumopathie chronique obstructive, l'hypertension pulmonaire, l'emphysème, l'asthme, la mucoviscidose et la bronchite.

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