Therapeutic agent for keratoconjunctival disorder

A - Human Necessities – 61 – K

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Details

A61K 31/427 (2006.01) A61P 27/02 (2006.01) A61P 27/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2543452

Novel pharmaceutical use of 5-[4-(6-methoxy-1-methyl-1H-benzoimidazol-2- ylmethoxy)benzyl]thiazolidine-2,4-dione being a condensed heterocyclic compound, or a salt thereof. This 5-[4-(6-methoxy-1-methyl-1H-benzoimidazol-2- ylmethoxy)benzyl]thiazolidine-2,4-dione or salt thereof can exert excellent curing accelerating effect with respect to dry eye models and is useful as a therapeutic agent for keratoconjunctive disorders, such as dry eye, corneal ulcer, keratitis, conjunctivitis, superficial punctate corneal disorder, corneal epithelial loss, conjunctival epithelial loss, keratoconjunctivitis sicca, superior limbic keratoconjunctivitis and filamentary keratitis.

La présente invention concerne une nouvelle utilisation pharmaceutique de 5-[4-(6-méthoxy-1-méthyl-1H-benzoimidazol-2-ylméthoxy)benzyl]thiazolidine-2,4-dione qui est un composé hétérocyclique condensé, ou un sel de celle-ci. Cette 5-[4-(6-méthoxy-1-méthyl-1H-benzoimidazol-2-ylméthoxy)benzyl]thiazolidine-2,4-dione ou son sel peut avoir un excellent effet d'accélération de durcissement vis-à-vis de modèles de sécheresse oculaire, et est utile en tant qu'agent thérapeutique pour traiter des troubles kératoconjonctifs tels que la sécheresse oculaire, l'ulcère cornéen, la kératite, la conjonctivite, les troubles cornéens ponctués superficiels, la perte de l'épithélium cornéen, la perte de l'épithélium conjonctif, la kératoconjonctivite sèche, la kératoconjonctivite limbique supérieure et la kératite filamentaire.

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