Bicyclic piperidine derivatives as melanocortin-4 receptor...

Details Bicyclic piperidine derivatives as melanocortin-4 receptor... Bicyclic piperidine derivatives as melanocortin-4 receptor...

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01) A61K 31/46 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 15/00 (2006.01) A61P 15/10 (2006.01)

Patent

CA 2519939

Certain novel bicyclic N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Certains nouveaux dérivés de piperidine bicycliques N-acylés sont des agonistes du ou des récepteur(s) humain(s) de la mélanocortine et, en particulier, des agonistes sélectifs du récepteur humain 4 de la mélanocortine (MC-4R). On les utilise pour traiter, contrôler ou prévenir des maladies ou des troubles sensibles à l'activation de MC-4R, tels que l'obésité, les diabètes, le dysfonctionnement sexuel, notamment le dysfonctionnement de l'érection et un dysfonctionnement sexuel de la femme.

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