Receptor assay for fk-506

Details Receptor assay for fk-506 Receptor assay for fk-506

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) C07K 2/00 (2006.01) C07K 4/12 (2006.01) C07K 14/72 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2063580

A competitive receptor assay for FK-506 and biologically-active metabolites, derivatives and analogues thereof is dis- closed, wherein the binding reagent is a specific FK-506 receptor protein either purified from the soluble cytoplasm of target cells of FK-506 action, particularly normal or transformed lymphocytes, freshly collected or in established cell lines, or synthesized by recombinant DNA techniques. Solution phase and solid state assay systems are disclosed.

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