New piperidine antibiotics

Details New piperidine antibiotics New piperidine antibiotics

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/4709 (2006.01) A61P 31/04 (2006.01) C07D 405/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2581057

The invention relates to novel, antibacterially active piperidine derivatives of the formula (I) wherein one of U and V represents N, the other represents N or CH; M represents CH2CH2, CH=CH, CH(OH)CH(OH), CH(OH)CH2, CH(NH2)CH2, COCH2 or OCH2; R1 represents alkyl, haloalkyl, alkoxy, haloalkoxy, halogen or cyano; R2 represents hydrogen or halogen; R3 represents carboxy, carboxamido, alkylaminocarbonyl, hydroxy, aminocarbonyloxy, 2-tetrazolyl or 3-methyl-1,2,4- oxadiazol-5-yl; R4 represents alkyl, (C1-C4)alkoxy-(C1-C4)alkyl, haloalkyl, alkenyl, arylalkyl, aryl-S(O)m-~alkyl, heteroarylalkyl, heteroarylaminocarbonylalkyl, heteroaryl-S(O)m-alkyl, CH2-CH=CH~aryl or cycloalkyl-S(O)m-alkyl; n is an integer from 0 to 3; and m is 0o r2.

L'invention concerne de nouveaux dérivés actifs de pipéridine antibactériens représentés par la formule (I), dans laquelle U ou V représente N, l'autre représentant N ou CH; M représente CH2CH2, CH=CH, CH(OH)CH(OH), CH(OH)CH2, CH(NH2)CH2, COCH2 ou OCH2; R1 représente alkyle, haloalkyle, alcoxy, haloalcoxy, halogène ou cyano; R2 représente hydrogène ou halogène; R3 représente carboxy, carboxamido, alkylaminocarbonyle, hydroxy, aminocarbonyloxy, 2-tétrazolyle ou 3-méthyl-1,2,4-oxadiazol-5-yle; R4 représente alkyle, (C1-C4)alcoxy-(C1-C4)alkyle, haloalkyle, alcényle, arylalkyle, aryl-S(O)m-alkyle, hétéroarylalkyle, hétéroarylaminocarbonylalkyle, hétéroaryl-S(O)m-alkyle, CH2-CH=CH-aryle ou cycloalkyl-S(O)m-alkyle; n représente un nombre entier compris entre 0 et 3; et m égale 0 ou 2.

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