Liver-specific nucleic acid regulatory elements and methods...

Details Liver-specific nucleic acid regulatory elements and methods... Liver-specific nucleic acid regulatory elements and methods...

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 38/36 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) A61P 7/04 (2006.01) C12N 15/85 (2006.01) C12N 15/864 (2006.01) C12N 15/867 (2006.01) C07K 14/745 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2722238

The present invention relates to nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy.

La présente invention concerne des éléments régulateurs dacide nucléique qui sont capables damplifier lexpression spécifique du foie de gènes, des procédés employant ces éléments régulateurs et des utilisations de ces éléments. Linvention concerne également des cassettes et des vecteurs dexpression contenant ces éléments régulateurs dacide nucléique. La présente invention est particulièrement utile pour des applications faisant appel à la thérapie génique.

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