Methods for increasing adiponectin

Details Methods for increasing adiponectin Methods for increasing adiponectin

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 3/04 (2006.01) A61P 5/50 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2749544

In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-activin A and/or B antibodies, anti-myostatin antibodies, anti- GDF3 antibodies, and anti-BMP7 antibodies. Also provided are methods for ameliorating one or more undesired effects of anti-androgen therapy, in-cluding muscle loss, bone loss, increased adiposity, and/or increased insulin resistance. A variety of disorders may be treated by causing an increase in circulating adiponectin concentrations.

Sous certains de ses aspects, la présente invention concerne des compositions et des procédés permettant d'augmenter l'adiponectine chez un patient le nécessitant, par l'administration d'un antagoniste d'une voie de signalisation ActRIIB. De tels antagonistes peuvent par exemple inclure les polypeptides ActRIIB, les anticorps anti-ActRIIB, les anticorps anti-activine A et/ou B, les anticorps anti-myostatine, les anticorps anti-GDF3 et les anticorps anti-BMP7. L'invention concerne aussi des procédés permettant d'améliorer un ou plusieurs effets indésirables de la thérapie anti-androgène, notamment la perte musculaire, la perte osseuse, l'augmentation de l'adiposité et/ou l'augmentation de la résistance à l'insuline. Divers troubles peuvent être traités en provoquant une augmentation des concentrations d'adiponectine en circulation.

Affiliated with

Also associated with

Rating

Methods for increasing adiponectin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for increasing adiponectin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for increasing adiponectin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1682417