Ply-gbs mutant lysins

Details Ply-gbs mutant lysins Ply-gbs mutant lysins

C - Chemistry, Metallurgy

12

N

C12N 9/78 (2006.01) A61K 38/00 (2006.01) C07K 14/005 (2006.01) C07K 14/01 (2006.01) C12N 9/80 (2006.01)

Patent

CA 2620903

Methods, compositions and articles of manufacture useful for the treatment of various Group B streptococci (GBS) bacteria are provided. Various bacterial lysins, including certain PIyGBS mutant lysins, are provided. In particular, PIyGBS mutant lysins having lytic killing activity against Group B streptococci (GBS) bacteria are provided, including PIyGBS mutant lysins with greater killing activity against Group B streptococci (GBS) bacteria than the non- mutated PIyGBS bacterial lysin.

L'invention porte sur des méthodes, des compositions et des articles de fabrication utiles dans le traitement de diverses bactéries streptocoques du groupe B (GBS). L'invention décrit diverses lysines bactériennes, y compris certaines lysines de mutant PlyGBS. L'invention décrit en particulier des lysines de mutant PIyGBS présentant une activité d'inhibition lytique des bactéries streptocoques du groupe N (GBS), y compris des lysines de mutant PlyGBS ayant une activité inhibitrice des bactéries streptocoques du groupe B plus élevée que la lysine bactérienne PlyGBS non mutée.

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