Human tumor necrosis factor receptor tr10

Details Human tumor necrosis factor receptor tr10 Human tumor necrosis factor receptor tr10

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/19 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2292790

The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.

Cette invention concerne une nouvelle protéine, appelée TR10, qui est un membre de la superfamille des récepteurs du facteur de nécrose tumorale (TNF) et de la sous-famille des récepteurs TRAIL. On décrit plus particulièrement des molécules d'acides nucléiques isolées qui codent la protéine TR10 humaine. On décrit également des polypeptides TR10 ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison utilisés pour produire ces derniers. Cette invention concerne également des procédés de criblage permettant d'identifier des agonistes et des antagonistes de l'activité de TR10.

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