Methods of using wisp antagonists

Details Methods of using wisp antagonists Methods of using wisp antagonists

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2536396

Methods and compositions for use in blocking or inhibiting the activity(s) of WISP-1 polypeptide on chondrocytes are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize the effects of WISP-1 on mammalian chondrocytes.

La présente invention se rapporte à des procédés et à des compositions permettant de bloquer ou d'inhiber la ou les activités du polypeptide WISP-1 sur les chondrocytes. Des antagonistes de WISP-1 comprennent des anticorps dirigés contre WISP-1, des immunoadhésines de WISP-1 et des variantes de WISP-1 (et des protéines hybrides de celles-ci), qui inhibent ou neutralisent les effets de WISP-1 sur les chondrocytes de mammifères.

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