Ribozymes targeted to il-15 mrna

Details Ribozymes targeted to il-15 mrna Ribozymes targeted to il-15 mrna

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2308018

Enzymatic RNA molecules which cleave mRNA encoding IL-15, are provided. The constructs of the invention include regulatory regions for expression in cells, cell lines, or transgenic non-human animals. The ribozymes of the invention are directed against IL-15 mRNA and are useful in treating rheumatoid arthritis.

Cette invention a trait à des molécules d'ARN qui coupent l'ARN messager codant l'interleukine 15 (IL-15). Les produits de recombinaison de l'invention consistent en des régions de régulation aux fins d'une expression dans des cellules, en des lignées cellulaires ou des animaux transgéniques. Les ribozymes de l'invention, qui sont dirigés à l'encontre de l'ARN messager d'IL-15, se révèlent efficaces dans le traitement de la polyarthrite rhumatoïde.

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