A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4453 (2006.01)
Patent
CA 2222739
A method for modulating calcium channels, increasing the density of calcium channels in vascular and cardiac tissue with no changes in inotropic or pressor response, comprising administering to a warm-blooded animal in need thereof a pharmaceutically-effective amount of a compound having formula (I) wherein R1 and R3 are independently hydrogen, C1-C4 alkyl, -CO-(C1-C6 alkyl), or -CH2Ar, -CO-Ar, wherein Ar is phenyl or substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically-acceptable salt thereof.
L'invention concerne un procédé pour moduler les canaux calciques et accroître leur densité dans les tissus vasculaires et cardiaques sans modifier la réponse inotrope ou vasopressive, consistant à administrer à un homéotherme, dont l'état le requiert, une dose pharmaceutiquement efficace d'un composé de formule (I) dans laquelle R?1¿ et R?3¿ sont indépendamment hydrogène, alkyle C¿1?-C¿4?, -CO-(alkyle C¿1?-C¿6?), ou bien -CH¿2?Ar, -CO-Ar, où Ar est phényle ou phényle substitué; R?2¿ est choisi dans le groupe composé de pyrrolidine, hexaméthylèneimino, et pipéridino; ou bien un sel pharmaceutiquement acceptable de ce composé.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
Modulation of calcium channels does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modulation of calcium channels, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of calcium channels will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1684228