C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) C12N 5/20 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2169951
It is the objective and purpose of the present invention to provide a novel and specific monoclonal antibody. This invention relates to a monoclonal antibody inhibiting the homing of hematopoietic stem cells and recognizing the surface antigen of a splenic stromal cell having potency supportive of the homing of hematopoietic stem cells and a hybridoma producing the monoclonal antibody. Since the monoclonal antibody of this invention has a characteristic of inhibiting the homing of hematopoietic stem cells, it is useful as medicine enhancing the effect of an anticancer agent for the clinical treatment of leukemia.
Un nouvel anticorps monoclonal inhibe la prise de cellules souches hématopoïétiques et reconnait l'antigène de surface d'une cellule interstitielle du pancréas capable de favoriser la prise de cellules souches hématopoïétiques. L'invention concerne également un hybridome produisant cet anticorps, ce dernier sert par exemple d'agent destiné à potentialiser des médicaments anti-cancéreux dans le traitement de la leucémie.
Chugai Seiyaku Kabushiki Kaisha
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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