Endoluminal prosthesis comprising a therapeutic agent

Details Endoluminal prosthesis comprising a therapeutic agent Endoluminal prosthesis comprising a therapeutic agent

A - Human Necessities

61

L

A61L 31/16 (2006.01) A61F 2/06 (2006.01) A61K 31/4045 (2006.01) A61L 29/16 (2006.01) A61M 25/00 (2006.01) A61P 9/00 (2006.01) C07D 209/16 (2006.01)

Patent

CA 2536961

Delivery of Melatonin (N-acetyl-5-methoxytryptamine) locally, particularly from an intraluminal prosthesis such as a coronary stent, directly from the surface of the prosthesis or from pores, micropores, or perforations in the stent body, mixed or bound to a polymer coating applied on the endoluminal prosthesis, or mixed or bound to a glue applied to the endoluminal prosthesis, to inhibit inflammation induced by the injury caused by the implantation of the prosthesis and neointimal tissue proliferation and ingrowth of tissue, thereby facilitating the performance of the prosthesis.

L'invention concerne l'administration de la mélatonine (N-acétyl-5-méthoxytryptamine) localement, en particulier à partir d'une prothèse intraluminale, par exemple une endoprothèse coronaire, directement de la surface de la prothèse, ou à partir des pores, micropores, ou perforations du corps de l'endoprothèse. La mélatonine est mélangée ou liée à un revêtement polymère ou à une colle appliqués sur la prothèse endoluminale en vue d'inhiber l'inflammation induite par la lésion due à l'implantation de la prothèse et la prolifération des tissus néointimaux et la croissance de tissus, ce qui facilite l'efficacité de la prothèse.

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