Pyrimidine inhibitors of erk protein kinase and uses therof

Details Pyrimidine inhibitors of erk protein kinase and uses therof Pyrimidine inhibitors of erk protein kinase and uses therof

C - Chemistry, Metallurgy

07

D

C07D 239/30 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2590250

Described herein are compounds that are useful as protein kinase inhibitors of formula (I); or a pharmaceutically acceptable salt thereof, wherein Ring A, Z1, Z2, U, Q, R1, R2, and L are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.

L'invention concerne des composés utilisés comme inhibiteurs de la protéine kinase, qui sont représentés par la formule (I); ou un sel pharmaceutiquement acceptable de ceux-ci. Dans cette formule, les cycles A, Z1, Z2, U, Q, R1, R2, et L sont tels que décrits dans le descriptif. Ces composés, ainsi que les compositions pharmaceutiquement acceptables de ceux-ci, sont utilisés pour traiter ou diminuer la gravité d'une variété de troubles, y compris les troubles prolifératifs tels que le cancer.

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