Recombinant human mannan-binding lectin

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2372435

The present invention relates to treatment of diseases and disorders of the immune system comprising treatment of deficiencies within the immune defence system. The invention concerns preparation of a novel expression construct encoding human MBL, a novel recombinant preparation of human MBL with high similarity to natural human MBL and futhermore it comprises use of this compound in compositions, medicaments and in methods for treatment of conditions such as those related to immunosuppressive conditions and/or to conditions of MBL deficiencies including latent conditions. Conditions of deficiencies of Mannan-Binding Lectin (MBL) are associated with increased susceptibility to infections. In more particular, the invention concerns treatment of said conditions, including latent conditions, i.e. although there is no present need. The treatment is aimed at humans and at animals, in which the immune system appears to act similarly to the human immune system.

La présente invention concerne le traitement de maladies et de troubles relatifs au système immunologique, qui comprend le traitement d'immunodéficiences dans le système de défenses immunologiques. Cette invention concerne la préparation d'une nouvelle construction d'expression codant pour une lactine se fixant à la mannane (MBL) humaine, une nouvelle préparation de recombinaison de MBL humaine qui présente de grandes analogies avec la MBL humaine naturelle, et l'utilisation de ces composés dans des compositions, des médicaments et dans des méthodes de traitement d'états tels que ceux qui ont traits aux états immunosuppresseurs et/ou aux immunodéficiences de la MBL, y compris les états latents. Les états liés aux déficiences de la lectine se fixant à la mannane (MBL) sont associés à une sensibilité accrue aux infections. Cette invention concerne plus particulièrement le traitement de ces états, y compris les états latents, c'est à dire en l'absence de toute nécessité absolue. Ce traitement est destiné aux hommes et aux animaux, pour lesquels le système immunologique semblent fonctionner d'une façon similaire au système immunologique de l'homme.

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