A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/40 (2006.01)
Patent
CA 2641026
The present invention discloses compositions which induce cross-activation of immune mediated and direct death signaling in targeted cells by exploiting the properties of a antibody/peptide-nucleic acid conjugate. The conjugate is able to simultaneously activate multiple death signaling mechanisms that are specifically targeted to neoplastic cells, including tumor cells. Methods of using the conjugate of the present invention as an immunotherapeutic modality for the treatment or prevention of neoplastic diseases or other disorders is also disclosed. Further, methods are disclosed for identifying such conjugates by assaying test agents for various cytotoxic responses, including the induction of hyperfusion between neoplastic cells in vitro.
La présente invention concerne des compositions qui induisent une activation croisée de la signalisation de la mort médiée par le système immunitaire et directe dans des cellules ciblées par l'exploitation des propriétés d'un conjugué anticorps/acide nucléique de polypeptides. Le conjugué est capable d'activer simultanément plusieurs mécanismes de signalisation de mort qui sont particulièrement ciblés sur des cellules néoplasiques, incluant des cellules cancéreuses. L'invention concerne également des procédés d'utilisation dudit conjugué en tant que modalité immunothérapeutique pour le traitement ou la prévention de maladies néoplasiques ou autres troubles. En outre, l'invention concerne des procédés d'identification de tels conjugués par l'analyse d'agents de test pour diverses réponses cytotoxiques, comprenant l'induction d'une hyperfusion entre des cellules néoplasiques in vitro.
Bedi Atul
Li Shulin
Ravi Rajani
Board Of Supervisors Of Louisiana State University And Agricultu
Mbm Intellectual Property Law Llp
The Johns Hopkins University
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