Stable lyophilized pharmaceutical preparations of g-csf

Details Stable lyophilized pharmaceutical preparations of g-csf Stable lyophilized pharmaceutical preparations of g-csf

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 9/14 (2006.01) A61K 9/19 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2151732

The present invention concerns lyophilized pharmaceutical preparations of G-CSF that contain maltose, cellobiose, gentiobiose, isomaltose, raffinose, sucrose or trehalose as stabilizing agents. In addition, the invention concerns a process for the production of stabilized lyophilisates as well as the use of maltose, cellobiose, gentiobiose, isomaltose, raffinose, sucrose or trehalose as stabilizing agents of pharmaceutical agents containing G-CSF. The preparations also contain a physiologically tolerated amount of a surfactant, in an amount no greater than the amount of G-CSF.

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