Spiro-piperidine derivatives

Details Spiro-piperidine derivatives Spiro-piperidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/438 (2006.01) A61P 9/02 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2670671

Present invention is concerned with novel indol-2-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. The compounds of present invention have the general Formula (I) wherein R1 to R11 and X are as defined in the description.

L'invention concerne de nouveaux dérivés d'indol-2-yl-carbonyl-spiro-pipéridine comme antagonistes des récepteurs V1a, la fabrication de ces dérivés, des compositions pharmaceutiques contenant ceux-ci et leur utilisation comme médicaments. Les composés actifs de l'invention sont utiles pour prévenir et/ou traiter, entre autres, les troubles anxieux et dépressifs. Les composés de l'invention sont représentés par la formule générale (I), dans laquelle R1 à R11 sont tels que définis dans le descriptif.

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