Use of a combination containing a non-nucleoside reverse...

A - Human Necessities – 61 – K

Patent

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A61K 31/55 (2006.01) A61K 31/00 (2006.01) A61K 31/353 (2006.01) A61K 31/427 (2006.01) A61K 31/551 (2006.01) A61K 31/554 (2006.01) A61K 31/7048 (2006.01) A61K 38/13 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2510143

An improved method for using a NNRTI in the treatment of HIV-1 infection, comprising administering to a human, needing treatment for HIV-1 infection, a therapeutically effective amount of said NNRTI or a pharmaceutically acceptable salt thereof, and an amount of an inhibitor of the cytochromes P450 that is sufficient to elevate, enhance, or extend plasma concentrations of said NNRTI.

L'invention concerne un procédé amélioré d'utilisation d'un INNTI dans le traitement d'une infection VIH-1, consistant à administrer à un être humain ayant besoin d'un traitement contre une infection VIH-1, une quantité efficace au niveau thérapeutique de cet INNTI ou d'un sel pharmaceutiquement acceptable de celui-ci, ainsi qu'une certaine quantité d'un inhibiteur des cytochromes P450 suffisante pour élever, améliorer ou augmenter les concentrations de plasma de cet INNTI.

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