Pyrimidines for use as plk inhibitors

Details Pyrimidines for use as plk inhibitors Pyrimidines for use as plk inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2565568

The invention relates to the compounds of formula (1), wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2 and R3 are defined as in claim 1. These compounds are suitable for use in the treatment of diseases which are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of these compounds in the production of a drug having the above-mentioned properties.

L'invention concerne des composés de formule (1), dans laquelle A, X, Y, Z, Ra, Rb, Rc, R1, R2 et R3 sont tels que définis à la revendication 1. Ces composés sont destinés au traitement de maladies caractérisées par une prolifération cellulaire anormale ou excessive. La présente invention porte également sur l'utilisation de ces composés pour réaliser un médicament présentant les propriétés susmentionnées.

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