Odorant receptors

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2380000

The invention provides methods and compositions relating to odorant receptors, including a general expression cloning methodology which is useful for identifying novel G protein-coupled receptors and a novel family of odorant receptors and related nucleic acids, ligands, agonists and antagonists. These compositions provide a wide variety of applications such as screening for related receptors, and by modulating the function of the disclosed receptors by modulating their expression or contacting them with agonists, antagonist or ligands modulating reproductive/sexual and non-sexual social behaviors mediated via the olfactory system, reproductive physiologies and olfactory system regulated feeding behaviors, migratory behaviors and events such as conception, implantation, estrous and menstruation.

L'invention porte sur des procédés et compositions relatifs à des récepteurs olfactifs dont une méthodologie de clonage par expression générale servant à identifier de nouveaux récepteurs couplés à la protéine G et une nouvelle famille de récepteurs olfactifs ainsi que les acides nucléiques, ligands, agonistes et antagonistes associés. Lesdites compositions ont une grande variétés d'applications telles que: le criblage de récepteurs associés, la modulation des fonctions du récepteur de l'invention en en modulant l'expression ou en les mettant en contact avec des agonistes, des antagonistes ou des ligands, la modulation des comportements sexuels de reproduction et des comportements sociaux non sexuels médiés par le système olfactif les physiologie de la reproduction, les comportements alimentaires régis par le système olfactif, les comportements migratoires et des événements tels que la conception, l'implantation, l'oestrus ou la menstruation.

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