Agents for imaging and diagnostic methods using them

Details Agents for imaging and diagnostic methods using them Agents for imaging and diagnostic methods using them

C - Chemistry, Metallurgy

07

C

C07C 311/42 (2006.01) A61K 49/06 (2006.01) A61K 51/04 (2006.01) C07C 323/25 (2006.01) C07C 323/58 (2006.01)

Patent

CA 2488219

The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser degree to cells having membranes of normal organization, and their uses as diagnostic probes. Said compounds and methods used therein may be useful in medical practice, for applications such as diagnosis of disease and monitoring of response to therapy.

La présente invention concerne de nouveaux composés qui se fixent de manière sélective à des cellules subissant des perturbations et des altérations au niveau de l'organisation normale de leur membrane plasmique, tout en se fixant à un moindre degré à des cellules présentant des membranes d'organisation normale, et leurs utilisations en tant que sondes diagnostiques. Lesdits composés et procédés utilisés dans l'invention peuvent être utiles dans la pratique médicale, pour des applications telles que le diagnostic d'une maladie et la surveillance d'une réponse à un traitement.

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