Novel human growth factors

Details Novel human growth factors Novel human growth factors

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/16 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2263894

The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. These proteins share homology with the XAG protein of Xenopus laevis and can be found in colon tissue. huXAG-1 is specifically found in cancerous colon cells and may therefore be a growth factor for colon cancer. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity as well as diagnostic and therapeutic uses of the proteins.

La présente invention concerne des protéines huXAG-1, huXAG-2 et huXAG-3, lesquelles sont de nouveaux facteurs de croissance humains. Ces protéines partagent une homologie avec la protéine XAG de Xenopuse laevis et peuvent être rencontrées dans les tissus du colon. La huXAG-1 est rencontrée spécifiquement dans des cellules cancéreuses du colon et peut être par conséquent un facteur de croissance du cancer du colon. L'invention concerne notamment des molécules d'acide nucléique isolées codant les protéines huXAG-1, huXAG-2 et huXAG-3. De plus, l'invention concerne des polypeptides huXAG-1, huXAG-2 et huXAG-3, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison destinés à leur production. En outre, l'invention concerne des procédés de criblage destinés à identifier des agonistes et des antagonistes de l'activité huXAG-1, huXAG-2 ou huXAG-3, ainsi que les utilisations diagnostiques et thérapeutiques des protéines.

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