Preparations for oral administration

Details Preparations for oral administration Preparations for oral administration

A - Human Necessities

61

K

A61K 31/5377 (2006.01) A61K 9/20 (2006.01) A61K 31/506 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61P 15/10 (2006.01) C07D 403/14 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2420461

The present invention provides a preparation for oral administration containing a medicinal substance having cGMP-specific phosphodiesterase inhibitory activity and showing decrease of solubility in the neutral and alkaline regions, wherein an acidic substance is compounded to promote the dissolution of the medicinal substance in the digestive tract and thus the efficacy can expressed promptly after administration. The preparation of the present invention is useful in the treatment of erectile dysfunction.

L'invention concerne des préparations destinées à être administrées par voie orale. Ces préparations sont efficaces dans le traitement de patients atteints de dysérection. Elles contiennent, en tant qu'ingrédient actif, un médicament présentant une solubilité réduite dans les zones neutre et alcaline, ainsi qu'un effet inhibiteur de la phosphodiestérase spécifique à cGMP. On utilise une substance acide pour favoriser la libération de ce médicament dans le système digestif, ledit médicament pouvant ainsi agir peu de temps après son administration.

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