A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01)
Patent
CA 2244063
A method of increasing sphincter competence comprising administering to a human in need of treatment an effective amount of a compound having formula (I), wherein R1 and R3 are independently hydrogen, -CH3, (a) or (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidino, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof. Also encompassed by the invention is a method of inhibiting urinary or fecal incontinence, or gastroesophageal disease or its symptoms, which includes administering to a human in need thereof an effective amount of a compound of formula (I).
Méthode permettant d'accroître l'efficacité des sphincters consistant à administrer à un sujet humain nécessitant un traitement une quantité efficace d'un composé de formule (I), dans laquelle R?1¿ et R?3¿ sont indépendamment hydrogène, -CH¿3?, a) ou b), Ar étant un phényle éventuellement substitué; R?2¿ est choisi dans l'ensemble constitué de pyrrolidino, hexaméthylèneimino, et pipéridino ou est un sel de solvate pharmaceutiquement acceptable de ceux-ci. L'invention concerne également une méthode d'inhibition de l'incontinence urinaire ou fécale, du reflux gastro-oesophagien ou de leurs symptômes, consistant à administrer à un sujet humain nécessitant ce traitement une quantité efficace d'un composé de formule (I).
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
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