Uses of vascular endothelial growth factor in the treatment...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) A61K 38/18 (2006.01) A61K 38/24 (2006.01) A61K 38/27 (2006.01)

Patent

CA 2360058

This invention provides a method of increasing or maintaining the blood supply in the penis of a male subject which comprises administering to the subject an amount of vascular endothelial growth factor effective to increase or maintain the blood supply in the subject's penis. This invention provides a method of treating erectile dysfunction in a subject which comprises administering to the subject an amount of vascular endothelial growth factor effective to increase the blood supply in the subject's penis and thereby treat the subject's erectile dysfunction. This invention provides a method of increasing or maintaining the blood supply in the penis of a subject which comprises introducing a nucleic acid comprising a gene encoding a vascular endothelial growth factor into a suitable cell under conditions such that the nucleic acid expresses vascular endothelial growth factor so as to thereby increase or maintain the blood supply in the subject's penis. This invention provides a method of increasing or maintaining the blood supply in the genital area of a female subject which comprises administering to the subject an amount of vascular endothelial growth factor effective to increase or maintain the blood supply in the subject's genital area.

L'invention concerne un procédé permettant d'augmenter ou d'entretenir l'irrigation sanguine du pénis chez un sujet mâle et consistant en l'administration à ce sujet d'une quantité suffisante de VEGF (Vascular Endothelial Growth Factor) ou "facteur de croissance vasculaire endothéliale" pour augmenter ou entretenir l'irrigation sanguine du peins du sujet. L'invention concerne un procédé permettant de traiter la dysérection chez un sujet, et consistant en l'administration au sujet d'une quantité de VEGF suffisante pour augmenter l'irrigation sanguine du pénis du sujet et ainsi de traiter la dysérection du sujet. L'invention concerne un procédé permettant d'augmenter ou d'entretenir l'irrigation sanguine du pénis chez un sujet mâle et consistant en l'introduction d'un acide nucléique comprenant un gène codant pour un VEGF introduit dans une cellule appropriée dans des conditions telles que l'acide nucléique vienne exprimer le VEGF de façon à augmenter ou entretenir l'irrigation sanguine du pénis du sujet. L'invention concerne un procédé permettant d'augmenter ou d'entretenir l'irrigation sanguine de la sphère génitale d'un sujet femelle et consistant en l'administration à ce sujet d'une quantité de VEGF suffisante pour augmenter l'irrigation sanguine de la sphère génitale du sujet.

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