C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2496295
Novel pyrazole derivatives of Formula (Ia), intermediates for their preparation, pharmaceutical compositions containing them and their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-.beta. signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
L'invention concerne de nouveaux composés de pyrazole, ainsi que des dérivés de ceux-ci, des intermédiaires permettant de les préparer, des compositions pharmaceutiques contenant ces composés et leurs utilisations médicinales. Les composés décrits sont de puissants inhibiteurs de la voie de signalisation du facteur de croissance transformant (TGF)-.beta.. Ces composés peuvent servir au traitement de divers états pathologiques associés au TGF, par exemple du cancer et des affections fibrotiques.
Blumberg Laura Cook
Munchhof Michael John
Pfizer Products Inc.
Torys Llp
LandOfFree
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