Immunostimulant compositions comprising an aminoalkyl...

Details Immunostimulant compositions comprising an aminoalkyl... Immunostimulant compositions comprising an aminoalkyl...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2396762

The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising RC-529 (an aminoalkyl glucosaminide phosphate compound) and QS-21 (a saponin). Such compositions synergistically enhance the immune response in a mammal to a co-administered antigen. Also provided are methods of using the compositions in the treatment of various human diseases, including cancer, microbial infections and autoimmune disorders.

La présente invention concerne des compositions pharmaceutiques, en particulier des compositions de vaccins, qui font appel à un système adjuvant comprenant du RC-529 ( un composé de phosphate d'aminoalkyl glucosaminide) et du QS-21 (une saponine). Les compositions de l'invention favorisent par synergie la réponse immunitaire d'un mammifère envers un antigène co-administré. L'invention se rapporte également à des procédés permettant d'utiliser les compositions précitées dans le traitement de diverses maladies humaines, y compris le cancer, les infections microbiennes et les maladies auto-immunes.

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