The nip3 family of proteins

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 47/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2311170

The present invention provides an isolated and purified Nip, Nix and Nox proteins. There is also provided a method for inducing apoptosis in cells by transfecting a cell with a Nip, Nix and Nox proteins. Additionally, there is provided a method for inducing apoptosis in cells by creating antibodies which recognize a specific Nip, Nix and Nox proteins in a muscle or skin of a patient. A method for inducing apoptosis in cells by creating a transgene overexpressing the gene for the Nip, Nix and Nox proteins is also provided. A transgenic animal and progeny thereof is provided having an expression factor consisting essentially of a Nip, Nix and Nox proteins selected from the group consisting essentially of Seq. ID No:1 through 6.

La présente invention concerne des protéines Nip, Nix et Nox purifiées et isolées, ainsi qu'un procédé d'induction de l'apoptose dans des cellules par transfection desdites cellules avec des protéines Nip, Nix et Nox. Elle concerne en outre un procédé d'induction de l'apoptose dans des cellules par création d'anticorps qui reconnaissent des protéines Nip, Nix et Nox spécifiques dans un muscle ou dans la peau d'un patient. Elle concerne encore un procédé d'induction de l'apoptose dans des cellules par création d'un transgène surexprimant le gène pour les protéines Nip, Nix et Nox. Elle concerne enfin un animal transgénique et sa descendance, possédant un facteur d'expression constitué essentiellement de protéines Nip, Nix et Nox choisies dans le groupe constitué essentiellement des Seq. ID No 1 à 6.

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