Atp-dependent protease and use of inhibitors for same in the...

Details Atp-dependent protease and use of inhibitors for same in the... Atp-dependent protease and use of inhibitors for same in the...

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/57 (2006.01) A61K 39/395 (2006.01) C07K 1/16 (2006.01) C07K 14/81 (2006.01) C12N 9/99 (2006.01) C12N 15/57 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2102195

2102195 9220804 PCTABS00017 The ATP-ubiquitin-dependent process has been shown to be responsible for the excessive protein degration which occurs in conditions or disease states in which there is severe loss of body mass and negative nitrogen balance has been identified and key constituents in the process identified. A method of inhibiting the accelerated or enhanced proteolysis, a method of identifying inhibitors of the process, multipain and the proteasome inhibitor are the subject of the claimed invention.

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