G - Physics – 06 – F
Patent
G - Physics
06
F
G06F 19/20 (2011.01) G06F 19/24 (2011.01) C12Q 1/68 (2006.01)
Patent
CA 2554977
The present invention is a method to assist in the identification of single nucleotide polymorphisms (SNP) from microarray hybridization data. Data from hybridization protocols run on microarrays often have variations in the data resulting from variations in hybridization conditions and efficiencies and variations in optical intensities. An algorithm is described to screen the results to identify those data points most likely to be real SNPs as opposed to variations in the hybridization or sensing data.
La présente invention concerne une méthode utilisée pouvant contribuer à l'identification de polymorphismes mononucléotidiques (SNP) à partir de données d'hybridation de jeux ordonnés de microéchantillons. Les données issues de protocoles d'hybridation exécutés dans des jeux ordonnés de microéchantillons présentent souvent des variations qui résultent de variations des conditions et rendements de l'hybridation et de variations des intensités optiques. Un algorithme est décrit, qui analyse les résultats afin d'identifier les points de données qui sont très probablement de réels SNP par opposition aux variations des données d'hybridation ou de détection.
Albert Thomas J.
Molla Michael
Richmond Todd
Smith Steve
Gowling Lafleur Henderson Llp
Nimblegen Systems Inc.
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