Polo domain structure

Details Polo domain structure Polo domain structure

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 35/12 (2006.01) C07K 17/00 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2372412

The present invention relates to binding pockets of a polo domain. In particular, the invention relates to a crystal comprising a binding pocket of a polo domain. The crystal may be useful for modeling and/or synthesizing mimetics of a binding pocket or ligands that associate with the binding pocket. Such mimetics or ligands may be capable of acting as modulators of polo family kinases, and they may be useful for treating, inhibiting, or preventing diseases modulated by such kinases.

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