Use of vasopeptidase inhibitors in the treatment of nephropathy

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2490277

The invention describes the use of vasopeptidase inhibitors of the formula (I) for the treatment and/or prophylaxis of nephropathy in diabetic or non-diabetic patients, including diabetic or non-diabetic nephropathy, glomerulonephritis, glomerular sclerosis, nephrotic syndome, hypertensive nephrosclerosis, microalbuminuria or end stage renal disease, or insulin resistence or of metabolic diseases associated with advanced glycation end-products, such as diabetic complications, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, myocardial infarction and/or diabetic cardiomyopathy, or atherosclerosis or endothelial dysfunction.

L'invention concerne l'utilisation d'inhibiteurs de la vasopeptidase de formule (I) pour traiter et/ou prévenir : une néphropathie chez des patients diabétiques ou non diabétiques, y compris une néphropathie diabétique ou non diabétique, une glomérulonéphrite, une glomérulosclérose, un syndrome néphrotique, une néphrosclérose hypertensive, une microalbuminurie ou une maladie rénale en phase terminale ; ou une résistance à l'insuline ou des maladies métaboliques associées aux produits terminaux de glycation avancée, telles que des complications diabétiques, une neuropathie diabétique, une néphropathie diabétique, une rétinopathie diabétique, des cataractes, un infarctus du myocarde et/ou une myocardiopathie diabétique ; ou une arthérosclérose ou un dysfonctionnement endothélial.

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