Perfluoroalkyl-substituted benzoylguanidines, a process for...

Details Perfluoroalkyl-substituted benzoylguanidines, a process for... Perfluoroalkyl-substituted benzoylguanidines, a process for...

Category

C - Chemistry, Metallurgy

Subcategory

07

Subsubcategory

C

IPC codes

C07C 317/32 (2006.01) A61K 31/165 (2006.01) A61K 31/18 (2006.01) A61K 31/40 (2006.01) A61K 49/00 (2006.01) C07C 317/44 (2006.01) C07C 317/46 (2006.01) C07C 323/42 (2006.01) C07D 207/30 (2006.01)

Type

Patent

Patent number

CA 2149285

Description

A description is given of perfluoroalkyl-substituted benzoylguanidines of the formula I (see formula I) where R(1) is (C1-C6) -perfluoroalkyl-SO m; R(2) and R(3) are H, halogen, alk(yl)oxy), phenoxy; R(4) and R(5) are H, alkyl, Hal, CN, OR(7), NR(8)R(9), -(CH2)n-(CF2)o-CF3 and of the pharmacologically acceptable salts thereof; the compounds I are obtained by reacting a compound II (see formula II) with guanidine, L being a leaving group which is able readily to undergo nucleophilic substitution.

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