C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/06 (2006.01) A61K 31/4184 (2006.01) A61K 31/496 (2006.01) A61P 21/00 (2006.01) A61P 23/00 (2006.01) A61P 25/00 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/02 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2373921
The present invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for inducing and maintaining anaesthesia, sedation and muscle relaxation, as well as for combating febrile convulsions in children. The compounds of the invention may also be used by veterinarians.
La présente invention concerne des dérivés de benzimidazole, des compositions pharmaceutiques contenant ces composés, et des techniques de traitement mettant en oeuvre ces compositions. Ces composés sont utiles dans le traitement de maladies et de troubles du système nerveux central, et plus précisément les états qui réagissent à la modulation de complexe du récepteur GABAA, notamment pour induire et maintenir une anesthésie, un effet sédatif et un relâchement musculaire, de même que pour combattre les convulsions fébriles chez les enfants. Les composés de cette invention conviennent aussi pour un usage vétérinaire.
Teuber Lene
Watjen Frank
Mccarthy Tetrault Llp
Neurosearch A/s
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