C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2328496
The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.
La présente invention a trait à de nouveaux polypeptides qui présentent des séquences identiques à celles d'IL-17, et à des molécules d'acides nucléiques codant pour ces polypeptides. L'invention concerne également des vecteurs et des cellules hôtes comprenant ces séquences d'acides nucléiques, des molécules de polypeptide chimère comprenant les polypeptides de l'invention fusionnés à des séquences de polypeptide hétérologue, des anticorps se liant aux polypeptides de l'invention et des procédés de production de ces polypeptides. L'invention concerne en outre des méthodes de traitement d'affections cartilagineuses dégénératives.
Chen Jian
Filvaroff Ellen
Goddard Audrey
Gurney Austin L.
Li Hanzhong
Dennison Associates
Genentech Inc.
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