A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/10 (2006.01) A61K 31/167 (2006.01) C07K 7/08 (2006.01) C07K 14/775 (2006.01)
Patent
CA 2659655
This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues when orally administered in conjunction with a peptide pharmaceutical (e.g., a class A amphipathic helical peptide as described herein) significantly increases the bioavailability of that peptide. Methods of peptide delivery using such "delivery agents" and pharmaceutical formulations are provided.
La présente invention concerne la découverte surprenante que l'administration par voie orale de salicylanilides, notamment la niclosamide et/ou certains de ses analogues, en association avec un peptide pharmaceutique tel qu'un peptide hélicoïdal amphipathique de classe A tel que décrit ici, augmente notablement la biodisponibilité de ce peptide. L'invention concerne également, d'une part des procédés d'administration de ces peptides au moyen d'agents d'administration, et d'autre part des formulations pharmaceutiques correspondantes.
Fogelman Alan M.
Navab Mohamad
Cassan Maclean
The Regents Of The University Of California
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