Process for the preparation of donepezil hydrochloride

Details Process for the preparation of donepezil hydrochloride Process for the preparation of donepezil hydrochloride

C - Chemistry, Metallurgy

07

D

C07D 211/32 (2006.01) A61K 31/445 (2006.01) A61P 25/28 (2006.01) C07D 211/02 (2006.01)

Patent

CA 2719164

The present invention provides a process for preparing donepezil or a salt thereof, the process comprising reducing a 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2- yl)methylene]pyridonium halide of formula (II), wherein X is bromide or chloride, in the presence of an ionic compound, a solvent, a catalyst and a source of hydrogen, to form donepezil and optionally converting the donepezil to the salt thereof.

L'invention porte sur un procédé de préparation de donépézil ou d'un de ses sels, consistant: à réduire un halogénure de 1-benzyl-4-[(5,6-diméthoxy-1-indanon-2-yl)méthylène]pyridonium de formule (II) dans laquelle X représente bromure ou chlorure, en présence d'un composé ionique, d'un solvant, d'un catalyseur et d'une source d'hydrogène, pour former le donépézil, puis facultativement à convertir le donépézil en l'un de ses sels.

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